Background: Head and neck cancer (HNC) is a notorious killer disease. Globally, more than 55,000 people are newly diagnosed to have the disease. Knowledge of disease among the public goes a long way in its prevention in society. Hence, this study aimed to explore the knowledge level of college freshmen on HNC disease and its risk factors. Methods: This study surveyed 224 college freshmen of the Sultan Abdur-Rahaman School of Health Technology, Gwadabawa, Sokoto State, Nigeria, on HNC disease and its risk factors, using an anonymous questionnaire. Data collected were analyzed using the SPSS version 20 software. Results: The mean