The Human immunodeficiency virus (HIV) is a lentivirus that causes HIV infection, and over time Acquired immunodeficiency syndrome (AIDS). HIV infection (simply called HIV at its early stage; while AIDS at its later stage) is a very prevalent disease condition affecting about 36.7 million people, both young and old, globally. Sadly, HIV/AIDS affect almost all the systems in the body (particularly the neurological and musculoskeletal systems), which may result into physical disability. Physiotherapists are known to play important roles in the management of physical disability. In this paper, authors gave a discuss on the clinical and epidemiological features of HIV/AIDS