Pain management is a very important aspect in the holistic care of patients. The clinical practitioner’s knowledge of the pharmacology of pain killers goes a long way in the effective control of pain. Objectives: To assess the level of knowledge of clinical practitioners in Sokoto metropolis, Nigeria, on the pharmacology of non-opioid analgesics (NOAs). Methods: This study utilized the primary data obtained from a cross-section of 175 clinical practitioners working in five randomly selected hospitals situated within the metropolitan city of Sokoto, Nigeria. The study tool was a 17-item questionnaire. Data analysis was done using the SPSS version 16 Software.