To determine the prevalence of the use of stimulants, narcotics, and hallucinogens among long distance commercial drivers in Sokoto City, Nigeria; to also explore their knowledge on the harmful effects of these psychoactive substances. Methods: this study surveyed a cross-section of 280 long distance commercial drivers in Sokoto City, Nigeria. The study tool was a semi-structured interviewer administered questionnaire. Data collected was analyzed using the SPSS Version 20 Software. Results: All the subjects, 280 (100%), were males with the mean age (±SD) of 40.63 (±10.09) years. Majority, 265 (94.6%), of them were Muslims while most of them (90.4%) were married.