Background: Human papillomavirus (HPV) is a notorious virus that is responsible for some cancers in the human body. This study aims to explore the knowledge of a sample of freshmen of the Sultan Abdur-Rahman School of Health Technology, Gwadabawa, Sokoto State, Nigeria, on HPV, HPV-induced cancers and HPV vaccines. Methods: This study surveyed 224 freshmen of the Sultan Abdur-Rahman School of Health Technology, Gwadabawa, on HPV, HPV-induced cancers and HPV vaccines, using a paper questionnaire. Data collected were analyzed using SPSS Version 20 Software. Results: The mean (± SD) age of the surveyed freshmen was 22.04 (± 3.42) years. Only